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Evidence that 5‐hydroxytryptamine in the forebrain is involved in naloxone‐precipitated jumping in morphine‐dependent rats
Author(s) -
Cervo L.,
Romandini S.,
Samanin R.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb10546.x
Subject(s) - jumping , morphine , forebrain , (+) naloxone , endocrinology , medicine , tegmentum , opioid , central nervous system , midbrain , receptor , physiology
1 A withdrawal syndrome was precipitated by naloxone in morphine‐dependent rats injected with 5,7‐dihydroxytryptamine (5,7‐DHT) in the ventromedial tegmentum (VMT) at the level of the nucleus interpeduncularis. 2 5,7‐DHT, which markedly depleted 5‐hydroxytryptamine (5‐HT) in the forebrain but not in the brainstem, significantly reduced jumping in abstinent rats with no significant effect on other withdrawal signs. 3 The effect of morphine 10 mg kg −1 on responses on the hot plate was unchanged in 5,7‐DHT‐treated rats. 4 The findings suggest that 5‐HT in the forebrain is selectively involved in the jumping of morphine‐abstinent rats.