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Effects of histamine and the histamine antagonists mepyramine and cimetidine on human coronary arteries in vitro
Author(s) -
Godfraind T.,
Miller R.C.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb10544.x
Subject(s) - mepyramine , cimetidine , histamine , contraction (grammar) , histamine h2 receptor , medicine , histamine h1 receptor , coronary arteries , endocrinology , histamine receptor , chemistry , pharmacology , receptor , artery , antagonist
1 The effects of histamine have been studied on human isolated coronary artery preparations taken from hearts ranging in age from 9 to 73 years. 2 Histamine in large concentrations (100 μ M ) contracted arteries which were without tone or spontaneous activity and sometimes induced rhythmic contractile activity. If spontaneous rhythmic activity was present it was enhanced by histamine. The contractile effects of histamine were inhibited by mepyramine but not by cimetidine. 3 Arteries which were contracted by depolarization responded with relaxation to histamine concentrations lower than those required to evoke a contraction; arteries from younger hearts were more sensitive than those from older hearts. 4 Mepyramine potentiated the maximal relaxant effect of histamine in arteries from hearts of all ages but cimetidine had very little effect. 5 In the presence of mepyramine, cimetidine antagonized the relaxant effect of histamine, shifting the concentration‐effect curve to the right. 6 It is concluded that human coronary arteries contain both H 1 ‐ and H 2 ‐type receptors, the H 1 ‐receptors mediating contraction. The relaxant effects of histamine can only be inhibited by a combination of both H 1 ‐ and H 2 ‐receptor antagonists.