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Influence of dopamine receptor agonists on gastric acid secretion induced by intraventricular administration of thyrotropin‐releasing hormone in the perfused stomach of anaesthetized rats
Author(s) -
MaedaHagiwara Masaki,
Watanabe Kazuo
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb10524.x
Subject(s) - apomorphine , bethanechol , endocrinology , medicine , gastric acid , bromocriptine , thyrotropin releasing hormone , dopamine , dopamine receptor , chemistry , stimulation , secretion , dopaminergic , pharmacology , prolactin , receptor , hormone , muscarinic acetylcholine receptor
1 The influence of dopamine receptor agonists on gastric acid secretion stimulated by thyrotropin‐releasing hormone (TRH) was studied in the perfused stomach of anaesthetized rats. 2 Intraventricular TRH produced a dose‐dependent stimulation of basal gastric acid secretion. 3 Pretreatment with apomorphine, bromocriptine or methamphetamine inhibited the TRH‐stimulated gastric acid secretion; these drugs did not influence bethanechol‐induced acid secretion. 4 Haloperidol and metoclopramide prevented the antisecretory effects of apomorphine, bromocriptine and methamphetamine. 5 The present study suggests that central dopamine receptor stimulation inhibits intraventricular TRH‐induced gastric acid secretion in rats.