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The effect of modification of sympathetic activity on responses to ligation of a coronary artery in the conscious rat
Author(s) -
Botting J.H.,
Johnston Kathleen M.,
Macleod B.A.,
Walker M.J.A.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb10520.x
Subject(s) - ligation , propranolol , medicine , blockade , sympathetic nervous system , anesthesia , cardiology , endocrinology , blood pressure , receptor
1 Ligation of a coronary artery was performed in conscious rats whose sympathetic system activity had been altered by various treatments. 2 β‐Adrenoceptor blockade with acute (0.2 mg kg −1 plus 0.1 μg kg −1 min −1 ) or chronic (50–60 mg kg −1 daily for 12 days) propranolol treatment had little effect on arrhythmias, or other responses to ligation. 3 Abrupt withdrawal of chronic propranolol two days before ligation was also without effect. 4 Reduction of sympathetic activity acutely with labetalol (5 mg kg −1 ), or chronically with adrenomedullectomy and 6‐hydroxydopamine treatment, accentuated the adverse effects of ligation. 5 The results of this study suggest that, while activity of the sympathetic system is not detrimental during ligation in the conscious rat, it may be important for survival.