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Prostaglandin synthesis inhibitors: effect on angiotensin II‐ and oxytocin‐induced contractions in rat uterine smooth muscle
Author(s) -
Hall M.M.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb10503.x
Subject(s) - nordihydroguaiaretic acid , endocrinology , medicine , oxytocin , angiotensin ii , lipoxygenase , chemistry , myometrium , carbachol , arachidonic acid , cyclooxygenase , renin–angiotensin system , prostaglandin , agonist , uterus , biology , biochemistry , receptor , enzyme , stimulation , blood pressure
1 Eicosatetraynoic acid, the acetylene analogue of arachidonic acid, which inhibits both the cyclo‐oxygenase and lipoxygenase pathways, reduced the contractile response of rat uterine smooth muscle to either angiotensin II or oxytocin. 2 Indomethacin, an inhibitor of cyclo‐oxygenase, did not reduce the response to angiotensin II but did abolish the contractile response to low doses of oxytocin. 3 Nordihydroguaiaretic acid, a lipoxygenase inhibitor, totally abolished the uterine response to either oxytocin or angiotensin II. 4 The contractile response to carbachol, a cholinoceptor agonist, was unaffected by pretreatment with any of the cyclo‐oxygenase or lipoxygenase inhibitors. 5 From these findings, it can be implied that some product of the arachidonate lipoxygenase pathway augments peptide‐induced contractions of the rat uterus.