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Effects of cocaine and desipramine on the neurally evoked overflow of endogenous noradrenaline from the rat heart
Author(s) -
Dart A.M.,
Dietz R.,
Kübier W.,
Schömig A.,
Strasser R.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb10497.x
Subject(s) - desipramine , stimulation , heart rate , medicine , endogeny , norepinephrine , endocrinology , anesthesia , chemistry , blood pressure , dopamine , antidepressant , hippocampus
1 Stimulation of postganglionic cardiac sympathetic nerves produced a stimulation frequency‐dependent overflow of endogenous noradrenaline from the otherwise isolated rat heart. 2 Such nerve stimulation also produced increases in heart rate. There was significant correlation between heart rate increases and corresponding noradrenaline concentrations in the coronary venous effluent. 3 Cocaine (3 × 10 −5 M ) caused a significant reduction in both the noradrenaline overflow and the heart rate increase, produced by nerve stimulation for 1 min at 4 Hz. 4 Desipramine (10 −6 M ) caused a significant increase in the noradrenaline overflow produced by stimulation for 1 min (4 Hz) with a mean increase of approximately 60%. There was no significant effect on the heart rate increase produced by such stimulation. 5 The opposite effects of cocaine (3 × 10 −5 M ) and desipramine (10 −6 M ) on noradrenaline overflow are attributed to differences in the local anaesthetic properties of these agents.