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Effect of angiotensin II and 5‐hydroxytryptamine on the vessels of the human foetal cotyledon
Author(s) -
Abramovich D.R.,
Page K.R.,
Wright F.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb10494.x
Subject(s) - cotyledon , angiotensin ii , umbilical cord , serotonin , endothelium , blood vessel , biology , in vitro , anatomy , endocrinology , medicine , biochemistry , botany , receptor , blood pressure
1 The actions of angiotensin II (AT II) and 5‐hydroxytryptamine (5‐HT) on the vessels of the human isolated, perfused, cotyledon were examined in vitro.2 The cotyledonary vessels were shown to respond to both AT II and 5‐HT over the range 10 −8 to 10 −4 M . 3 The preparation was found to be more responsive to AT II than 5‐HT. 4 The findings confirm that the responsiveness of the cotyledonary vessels differs from the vessels of the umbilical cord, and that this behaviour does not depend upon the integrity of the endothelium associated with these vessels.