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Blood pressure changes in spontaneously hypertensive rats correlate with aortic prostacyclin formation
Author(s) -
Fahr A.,
Förster W.,
Taube Ch.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb10490.x
Subject(s) - prostacyclin , blood pressure , prazosin , medicine , aorta , clonidine , endocrinology , platelet , thoracic aorta , aortic pressure , chemistry , antagonist , receptor
1 The relationship between the blood pressure fall, induced by antihypertensive drugs or bleeding, and the formation of prostacyclin (PGI 2 )‐like activity in the thoracic aorta of spontaneously hypertensive rats has been investigated. Inhibition of ADP‐induced platelet aggregation was used to assess PGI 2 ‐like activity. 2 The decreases in blood pressure produced by clonidine, dihydralazine and prazosin were associated with increases of PGI 2 ‐like activity of 50–80%. The increase in PGI 2 ‐like activity correlated well with the blood pressure decrease, independently of the mechanism of the fall in blood pressure.