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Spinal interneurone depression by DS103–282
Author(s) -
Curtis D.R.,
Leah J.D.,
Peet M.J.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb10487.x
Subject(s) - excitatory postsynaptic potential , postsynaptic potential , neuroscience , spinal cord , depression (economics) , chemistry , inhibitory postsynaptic potential , medicine , biology , receptor , macroeconomics , economics
The depressant effect of 5‐chloro‐4‐(2‐imidazolin‐2‐yl‐amino)‐2,1,3‐benzothiodiazole (DS 103–282) on the polysynaptic excitation of interneurones in the cat spinal cord appears to be related to a postsynaptic reduction in the effectiveness of excitatory transmitters rather than to interference with their presynaptic release.