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The effect of felodipine on ventricular fibrillation after coronary artery ligation in the anaesthetized pig
Author(s) -
Verdouw P.D.,
Wolffenbuttel B.H.R.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb10486.x
Subject(s) - felodipine , ventricular fibrillation , cardiology , medicine , propranolol , ligation , anesthesia , artery , coronary artery occlusion , blood pressure
A 10 min ligation of the left anterior descending coronary artery in anaesthetized pigs resulted in ventricular fibrillation (VF) in 70% of control and propranololtreated animals. Felodipine (10 nmol kg −1 ) not only reduced ventricular ectopic activity by 90%, but also completely abolished VF. When a second occlusion was applied after 20 min of reperfusion, felodipine was less effective against VF, possibly due to decreasing felodipine concentrations or only a transient increase in VF threshold.