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Indomethacin enhances the effect of histamine on airways resistance in the anaesthetized guinea‐pig
Author(s) -
Mitchell H.W.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb10032.x
Subject(s) - histamine , reserpine , propranolol , chemistry , guinea pig , pharmacology , endocrinology , medicine , basal (medicine) , insulin
1 In anaesthetized guinea‐pigs intravenous histamine caused an increase in airways resistance (R A ) and a fall in dynamic compliance (C Dyn ). 2 Indomethacin (1 mg kg −1 , i.v.) significantly enhanced the effect of histamine on R A . Indomethacin also increased the basal R A and the R A response to a histamine infusion. The effect of indomethacin on C Dyn was less consistent but here also there was a trend for an increased response to histamine. Sodium carbonate (the vehicle for indomethacin, 0.05 ml 100 m m solution) had no effect on R A or C Dyn in control experiments. 3 Propranolol (0.1 mg kg −1 , i.v.) enhanced the effect of histamine on R A in animals pretreated with either indomethacin or Na 2 CO 3 vehicle, but the effect was more consistent in indomethacin pretreated animals. 4 Indomethacin also tended to enhance the effect of histamine on R A in animals pretreated with reserpine or BW755c but it had little effect on the C Dyn response to histamine. 5 The results show that indomethacin augments the responsiveness of the airways to histamine in the anaesthetized guinea‐pig. The results with propranolol and reserpine suggest that an operational β‐adrenergic system is not required for the effect of indomethacin on R A . No confirmation for lipoxygenase involvement was obtained with the lipoxygenase inhibitor, BW755.