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In vivo release of [ 3 H]‐purines by quinolinic acid and related compounds
Author(s) -
Perkins M. N.,
Stone T. W.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb10029.x
Subject(s) - quinolinic acid , quinolinate , kynurenic acid , nmda receptor , kainate receptor , quisqualic acid , glutamate receptor , chemistry , biochemistry , aspartic acid , in vivo , purine metabolism , pharmacology , biology , kainic acid , amino acid , receptor , ampa receptor , tryptophan , microbiology and biotechnology , enzyme
1 In vivo release of [ 3 H]‐purines from the cortex of anaesthetized rats was measured and the actions of excitatory amino acids and analogues investigated. 2 High KCl, N‐methyl‐ dl ‐aspartate (NMDLA) and quinolinic acid produced a large increase in basal release of labelled materials. Glutamate, quisqualate and kainate had less effect. 3 The N‐methyl‐ d ‐aspartic acid (NMDA)‐preferring receptor antagonist, 2‐amino‐7‐phosphono‐heptanoic acid, significantly reduced the release evoked by NMDLA and quinolinate but not that produced by the other agonists. 4 Kynurenic acid, a compound metabolically related to quinolinic acid, reduced the release due to NMDLA and quinolinate but not glutamate. 5 The results add further support to the suggestion that quinolinic acid acts on the NMDA‐preferring receptor.