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Central nervous system effects of arachidonic acid, PGE 2 , PGF 2α , PGD 2 and PGI 2 on gastric secretion in the rat
Author(s) -
Puurunen Juhani
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb10028.x
Subject(s) - arachidonic acid , medicine , secretion , gastric acid , endocrinology , prostaglandin e , prostaglandins f , pepsin , prostaglandin , chemistry , biology , biochemistry , enzyme
1 The effects of arachidonic acid, prostaglandin E 2 (PGE 2 ), PGF 2α , PGD 2 and PGI 2 on gastric secretion (acid, pepsin and volume) after intracerebroventricular administration were investigated in conscious, pylorus‐ligated rats. 2 Arachidonic acid 30–1000 μg had no effect on gastric secretion. 3 PGE 2 3 and 10 μg, reduced gastric secretion as measured 1 hour after injection, although the inhibition induced by 3 μg disappeared by 2 h. 4 PGF 2α 10 and 30 μg, inhibited gastric secretion as measured after 1 h, whereas no change was observed in the gastric contents collected 2 h after 10 μg of PGF 2α . Intramuscular injection of 30 μg of PGF 2α had no effect on gastric secretion. 5 Intracerebroventricular administration of 1–30 μg of PGD 2 or PGI 2 had no effect on gastric secretion. 6 The results indicate that PGE 2 and PGF 2α have a potent central antisecretory action in conscious, pylorus‐ligated rats, whereas arachidonic acid, PGD 2 and PGI 2 do not have any central effects on gastric secretion. It is suggested that PGE 2 and PGF 2α may be involved in the central nervous system control of gastric secretion.