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Thyrotropin releasing hormone‐induced hyperthermia in mice: possible involvement of adrenal and pituitary glands
Author(s) -
Boschi Gabrielle,
Nomoto Teruko,
Rips Richard
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb10024.x
Subject(s) - medicine , endocrinology , hyperthermia , long term potentiation , hypophysectomy , adrenal medulla , thyrotropin releasing hormone , pituitary gland , hormone , medulla , chemistry , biology , catecholamine , receptor
1 To investigate the hyperthermic effect of thyrotropin releasing hormone (TRH) and its potentiation by exogenous catecholamines (CA), the role of the adrenal medulla and of the pituitary gland was studied in unoperated, adrenal‐demedullated or hypophysectomized mice. 2 In unoperated mice, TRH 40 mg kg −1 i.p. produced a hyperthermia which was accompanied by an increase in plasma noradrenaline (NA) and adrenaline (Ad). NA or Ad, both at a dose of 1 mg kg −1 i.p., enhanced the TRH‐induced hyperthermia. 3 Adrenal demedullation suppressed the hyperthermia and the increase of plasma CA produced by TRH but not the potentiation of this hyperthermia by exogenous CA. 4 Hypophysectomy abolished the TRH‐induced hyperthermia but not the increase of plasma CA or the potentiation of this hyperthermia by exogenous CA. 5 These results suggest that, in mice, both the adrenal medulla and the pituitary gland play an essential role in TRH‐induced hyperthermia but not in its potentiation.