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Spasmolytic effect of cadmium and cadmium uptake in aorta
Author(s) -
Nasu Tetsuyuki
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb10013.x
Subject(s) - cadmium , chemistry , aorta , cysteine , efflux , contraction (grammar) , biophysics , nuclear chemistry , biochemistry , medicine , endocrinology , biology , enzyme , organic chemistry
1 The relationship between inhibition of tension by Cd 2+ in aorta and the kinetics of cadmium uptake and efflux was studied. Cd 2+ (0.01–0.5 m m ) inhibited the contraction of aorta to high‐K + (30 m m ) in a dose‐dependent manner. 2 The high‐K + ‐induced tension completely returned to control values after 60 min washing with a solution containing 5 m m disodium edetate (EDTA) or 5 m m cysteine, following a treatment with 0.5 m m Cd 2+ for 30 min; after washing with normal medium only 15% of the control response returned. 3 Cadmium uptake increased with an increase of the Cd 2+ concentration (0.01–0.5 m m ). 4 Aortae preincubated with 0.5 m m Cd 2+ for 60 min were washed subsequently with a medium containing 5 m m EDTA or 5 m m cysteine. About 5% of the original tissue cadmium was retained after washing with EDTA or cysteine. 5 It is suggested that Cd 2+ binds chiefly to the surface membrane of aorta. It seems possible that the quantity bound is correlated with the degree of inhibition of tension.