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Evidence against vasoactive intestinal polypeptide (VIP) as a dilator and in favour of substance P as a constrictor in airway neurogenic responses
Author(s) -
Karlsson J.A.,
Persson C.G.A.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb09999.x
Subject(s) - vasoactive intestinal peptide , substance p , dilator , atropine , propranolol , carbachol , contraction (grammar) , endocrinology , medicine , guinea pig , tachykinin receptor , tachyphylaxis , neuropeptide , acetylcholine , chemistry , receptor , stimulation
Propranolol‐resistant neurogenic relaxation persisted in (carbachol‐contracted) guinea‐pig tracheae already relaxed by supramaximal concentrations of vasoactive intestinal polypeptide (VIP). Also, VIP relaxed preparations that were under neurogenic inhibition. In hilus bronchi, about 60% of a neurogenic contraction was atropine‐resistant. (Arg 5 , d ‐Trp 7,9 ) SP 5–11 specifically antagonized this contraction and those produced by exogenous substance P. Substance P, but not VIP, seems to be involved in nerve‐mediated effects on guinea‐pig airway tone.