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Antinociceptive actions of morphine and buprenorphine given intrathecally in the conscious rat
Author(s) -
Bryant Rosamunde M.,
Olley Jean E.,
Tyers M.B.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb09417.x
Subject(s) - buprenorphine , morphine , nociception , medicine , analgesic , anesthesia , intrathecal , ed50 , pharmacology , opiate , tail flick test , opioid , receptor
1 The antinociceptive effects of morphine and buprenorphine given intrathecally and subcutaneously have been compared in the conscious rat. 2 In the paw pressure test, when given subcutaneously buprenorphine 0.001–0.1 mg/kg s.c., was approximately 100 times more potent than morphine 0.1–3 mg/kg s.c., but in the hot plate test, buprenorphine 0.03–3.0 mg/kg s.c., produced a bell‐shaped dose‐response curve of low maximum effect and was about equipotent with morphine 0.03–3 mg/kg s.c. 3 When given intrathecally buprenorphine 10 μg and morphine, 10–60 μg, were approximately equipotent in both paw pressure and hot plate tests. Furthermore, morphine produced these effects at 1/25th of the minimum effective parenteral dose while the dose of buprenorphine exceeded the parenteral dose. 4 It is concluded that the predominant site of the analgesic action of buprenorphine is supraspinal. The significance of these findings in relation to the role of spinal opiate receptors is discussed.