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The role of nicotinic receptors in dog pancreatic exocrine secretion
Author(s) -
Devaux M.A.,
Diaz G.R.,
Kubota K.,
Magee D.F.,
Sarles H.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb09412.x
Subject(s) - secretin , pentagastrin , medicine , endocrinology , secretion , pancreatic juice , receptor , chemistry , pancreas , gastric acid
1 The effects of pentamethonium, an autonomic ganglion blocker, were studied on the exocrine pancreatic secretion of six conscious dogs given intravenous infusions of urecholine, caerulein or pentagastrin on a background of submaximal doses of secretin. 2 Urecholine‐induced protein secretion was not affected but both caerulein‐ and to a smaller extent, pentagastrin‐induced protein secretions were depressed by pentamethonium. 3 These results indicate that intravenous caerulein and pentagastrin, but not urecholine, act at least partially via nicotinic receptors. 4 Volume and bicarbonate output were depressed by pentamethonium when stimulated by intravenous caerulein with a background of secretin, but not when stimulated by pentagastrin on a background of secretin. 5 From these data it is suggested that caerulein and pentagastrin may potentiate secretin‐stimulated hydrelatic secretion by different mechanisms.