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Sodium cromoglycate, verapamil and nicardipine antagonism to leukotriene D 4 bronchoconstriction
Author(s) -
Advenier C.,
Cerrina J.,
Duroux P.,
Floch Anne,
Pradel J.,
Renier Annick
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb09395.x
Subject(s) - bronchoconstriction , nicardipine , verapamil , cromolyn sodium , sodium cromoglycate , pharmacology , antagonism , leukotriene , medicine , leukotriene c4 , anesthesia , asthma , calcium , receptor
1 The effects of nicardipine, verapamil and sodium cromoglycate (SCG) on the increase in pulmonary airway resistance(R Aw ) and decrease in pulmonary dynamic compliance (C Dyn ) induced by leukotriene D 4 (LTD 4 ) 0.5 μg kg −1 and acetylcholine (ACh) 3 μg kg −1 were investigated in anaesthetized guinea‐pigs. The effects of these three agents on the contractile effects of LTD 4 and ACh were tested on isolated tracheal preparations of the guinea‐pig. 2 Nicardipine and verapamil (0.3 and 1 mg kg −1 ), as well as SCG (3 and 10 mg kg −1 ), partially but significantly inhibited the effects of LTD 4 on R Aw . Partial inhibition of the effect of LTD 4 on C Dyn was only observed with verapamil (0.3 and 1 mg kg −1 ). Nicardipine and verapamil had no effect on ACh‐induced bronchoconstriction in vivo.3 In concentrations higher than 10 −5 m , nicardipine and verapamil inhibited the contractile effects of LTD 4 and ACh on guinea‐pig isolated trachea. SCG had no effect on this preparation. 4 These results suggest that nicardipine, verapamil and SCG partially reduce the component of bronchoconstriction associated with stimulation of irritant receptors by LTD 4 . However, the site and mechanism of action of Ca 2+ ‐entry antagonists remain uncertain.