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The effect of McN‐A‐343 on muscarinic receptors in the cerebral cortex and heart
Author(s) -
Birdsall N.J.M.,
Burgen A.S.V.,
Hulme E.C.,
Stockton J.M.,
Zigmond M.J.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb09388.x
Subject(s) - muscarinic acetylcholine receptor , agonist , muscarinic acetylcholine receptor m4 , muscarinic acetylcholine receptor m2 , muscarinic acetylcholine receptor m1 , receptor , neuroscience , cerebral cortex , muscarinic agonist , chemistry , endocrinology , medicine , muscarinic acetylcholine receptor m3 , pharmacology , biology
McN‐A‐343 behaves as a competitive agonist in binding to muscarinic receptors in the cerebral cortex. In its interaction with myocardial muscarinic receptors it is not competitive but it retains features of agonist binding.

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