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A role for 5‐hydroxytryptamine in the GABA‐mimetic potentiation of α‐flupenthixol‐induced catalepsy in the rat
Author(s) -
Davies John A.,
Williams John
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb09373.x
Subject(s) - catalepsy , long term potentiation , neuroscience , pharmacology , chemistry , medicine , psychology , haloperidol , receptor , dopamine
1 α‐Flupenthixol (α‐FPT)‐induced catalepsy in the rat was potentiated by diaminobutyric acid (DABA), an inhibitor of the neuronal high affinity uptake of γ‐aminobutyric acid (GABA). 2 The depletion of 5‐hydroxytryptamine (5‐HT) with p ‐chlorophenylalanine (PCPA) abolished the DAB A potentiation of α‐FPT‐induced catalepsy; this response was restored with 5‐hydroxytryptophan. 3 Potentiation of α‐FPT‐induced catalepsy by clonazepam was significantly reduced by methysergide. Conversely, the potentiation of catalepsy by clomipramine was significantly reduced by Picrotoxin. 4 These results are interpreted as evidence supporting a role for 5‐HT in modifying the GABA‐ergic inhibition of dopaminergic pathways, possibly by regulating the release of GABA.