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Inhibition of gastric acid secretion by intracerebroventricularly administered prostaglandin E 2 in anaesthetized rats
Author(s) -
Puurunen Juhani
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb09372.x
Subject(s) - endocrinology , medicine , gastric acid , prostaglandin e , stimulation , secretion , prostaglandin , acetylcholine , prostaglandin e2 , stomach , chemistry
1 The effect of intracerebroventricularly (i.c.v) administered prostaglandin E 2 (PGE 2 ) on gastric acid secretion was studied in anaesthetized rats. 2 Intracerebroventricular injections of 1 and 3 μg of PGE 2 inhibited gastric acid secretion induced by insulin, electrical vagal stimulation and acetylcholine in a dose‐dependent manner. 3 Intravenous injections of 1, 3 and 10 μg of PGE 2 had no effect on insulin‐stimulated gastric acid output. 4 The results indicate that upon i.c.v. administration PGE 2 inhibits gastric acid secretion by acting centrally and not peripherally after leakage from the central nervous system.