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Selective inhibition of thromboxane B 2 accumulation and metabolism in perfused guinea‐pig lung
Author(s) -
Hoult J.R.S.,
Robinson C.
Publication year - 1983
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1983.tb09366.x
Subject(s) - thromboxane , thromboxane a2 , guinea pig , thromboxane b2 , prostaglandin , chemistry , metabolism , prostaglandin e , agonist , thromboxane a synthase , endocrinology , medicine , pharmacology , biochemistry , biology , receptor , platelet
1 U46619, a prostaglandin H 2 endoperoxide analogue and thromboxane A 2 agonist, dose‐dependently inhibited accumulation and metabolism of thromboxane B 2 in the isolated perfused lung of the guinea‐pig. At similar doses prostaglandins E 1 , E 2 , F 2α , F 2α , I 2 , 5,6‐ trans ‐PGE 2 and 8‐ iso ‐PGE 1 were ineffective. 2 U46619 did not affect accumulation and metabolism of prostaglandin F 2α under similar conditions. 3 The pulmonary disposition of thromboxane B 2 , which occurs by uptake into pulmonary cells or binding to a specific macro molecular component, is mediated by a mechanism distinct from that handling prostaglandin F 2α . The possible relevance of these findings to the pulmonary disposition of thromboxane A 2 is discussed.