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EFFECT OF MUSCARINE ON RELEASE OF CATECHOLAMINES FROM THE PERFUSED ADRENAL GLAND OF THE CAT
Author(s) -
KIRPEKAR S.M.,
PRAT J.C.,
SCHIAVONE M.T.
Publication year - 1982
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1982.tb09318.x
Subject(s) - muscarine , endocrinology , adrenal gland , medicine , muscarinic acetylcholine receptor , chemistry , acetylcholine , catecholamine , adrenal medulla , nicotine , perfusion , biology , receptor
1 The secretory effect of muscarine was studied in the perfused adrenal gland of the cat. During perfusion of the adrenal gland with Krebs‐bicarbonate solution containing muscarine 480 μ m , the rate of catecholamine (CA) secretion was 2.02 ± 0.43 μg/2 min in the first 2 min; thereafter, CA output declined only moderately, to reach about 70% of the initial value after 10 min. Secretory responses to brief infusions of muscarine remained reproducible for at least the first 3 infusions. 2 When the adrenal gland was perfused with muscarine (480 μ m ), infusions of high K + , nicotine, or veratridine produced their usual responses. A 100 fold lower dose of muscarine also failed to modify these responses. 3 During perfusion with high K + , muscarine evoked a secretory response that was only slightly smaller than the response to muscarine alone. 4 It is concluded that muscarine and nicotine activate CA secretion in the cat adrenal gland by independent mechanisms and that the muscarinic response, unlike the nicotinic response, is not readily desensitized.