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THE EFFECT OF LEUKOTRIENE C 4 ON MUCIN RELEASE INTO THE CAT TRACHEA in vivo AND in vitro
Author(s) -
PEATFIELD A.C.,
PIPER PRISCILLA J.,
RICHARDSON P.S.
Publication year - 1982
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1982.tb09310.x
Subject(s) - in vivo , mucin , in vitro , chemistry , leukotriene , leukotriene d4 , pharmacology , biology , biochemistry , immunology , asthma , microbiology and biotechnology
We have tested the effect of leukotriene C4 (LTC4, 6 X 10(-8) to 6 X 10(-5) M) on the output of radiolabelled mucins from the trachea of the anaesthetized cat. Doses between 6 X 10(-7) M and 6 X 10(-5) M stimulated mucin release. FPL 55712 (9.5 X 10(-6) M) partially antagonized the effect of the highest dose of LTC4. Tests of LTC4 (6 X 10(-8) to 6 X 10(-6) M) on cat trachea in vitro failed to show any effect on mucin secretion. We conclude that leukotrienes may be one of the mediators of mucus secretion into the inflamed airway.