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FREQUENCY‐DEPENDENT DEPRESSION OF GANGLIONIC TRANSMISSION BY PROPRANOLOL AND DILTIAZEM IN THE SUPERIOR CERVICAL GANGLION OF THE GUINEA‐PIG
Author(s) -
ITO H.,
NISHI K.
Publication year - 1982
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1982.tb09305.x
Subject(s) - superior cervical ganglion , diltiazem , propranolol , sympathetic ganglion , ganglion , stimulation , guinea pig , cervical ganglia , neurotransmission , medicine , endocrinology , chemistry , calcium , anatomy , receptor
1 Effects of propranolol and diltiazem on ganglionic transmission in the superior cervical ganglion of the guinea‐pig were investigated with intracellular recording techniques. 2 Propranolol and diltiazem (5 × 10 −6 ‐10 −5 m ) induced a transmission failure in the ganglion upon preganglionic nerve stimulation at high frequency (25–30 Hz) without affecting action potentials induced by direct stimulation of the soma membrane, or potentials induced by iontophoretically applied acetylecholine. 3 The results suggest that propranolol and diltiazem may act on preganglionic nerve terminals to inhibit Ca 2+ influx in a frequency‐dependent manner. These agents may depress excess sympathetic activity without much affecting normal ganglionic transmission.