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EFFECTS OF KETAMINE AND OF HIGH PRESSURE ON THE RESPONSES TO γ‐AMINOBUTYRIC ACID OF THE RAT SUPERIOR CERVICAL GANGLION in vitro
Author(s) -
LITTLE HILARY J.
Publication year - 1982
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1982.tb09287.x
Subject(s) - ketamine , long term potentiation , superior cervical ganglion , ganglion , chemistry , agonist , anesthesia , neuroscience , pharmacology , medicine , biology , receptor
1 The method of Brown & Marsh (1974) for recording of surface potentials from the rat superior cervical ganglion has been adapted for use in a high pressure chamber in order to study the effects of high pressure of helium and the possible interactions with the effects of general anaesthetics. 2 Helium pressure of 130 atm did not alter the amplitude of the responses recorded from the ganglion in response to γ‐aminobutyric acid (GABA) application (9.7 and 19.4 μ m ) but the amplitude of responses to a nicotinic agonist were depressed. 3 Ketamine, at concentrations between 18 and 180 μ m , considerably potentiated the responses of the ganglion to GABA. 4 Helium pressure (130 atm) did not reverse the potentiation of GABA by ketamine. 5 The results are discussed in connection with the ability of ketamine to oppose the behavioural effects of high pressure.