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EFFECTS OF β‐ADRENOCEPTOR DRUG STIMULATION ON VARIOUS MODELS OF GASTRIC ULCER IN RATS
Author(s) -
ESPLUGUES JUAN,
LLORIS JOSÉ M.,
MARTÍBONMATÍ EZEQUIEL,
MORCILLO ESTEBAN J.
Publication year - 1982
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1982.tb09258.x
Subject(s) - stimulation , medicine , drug , pharmacology , parasympathomimetics , receptor , muscarinic acetylcholine receptor
1 Experiments were designed to evaluate the effect of the pharmacological activation of β‐adrenoceptors on various models of gastric ulcer in the rat. 2 Pretreatment with the β‐adrenoceptor stimulant drugs, isoprenaline or salbutamol, significantly inhibited stress‐induced gastric ulcers. This anti‐ulcer effect was abolished by propranolol but not by atenolol, suggesting that β 2 ‐adrenoceptors mediate this response. 3 In the pylorus‐ligation model, salbutamol inhibited lesion formation and reduced the intragastric content of hydrogen ions, histamine and pepsin although the latter was only affected with the higher dose of salbutamol. 4 Salbutamol also prevented the ulcerogenic action on the gastric mucosa of an exogenously perfused artificial gastric juice, showing that the anti‐ulcer effect is not necessarily dependent on acid inhibition. 5 Salbutamol also reduced the formation of acute ulcers induced by various iatrogenic means (histamine, polymyxin B, reserpine and indomethacin). 6 Long‐term treatment with salbutamol accelerated the healing of experimental chronic gastric ulcer. 7 In anaesthetized rats, salbutamol produced a dose‐related increase in mucosal blood flow which may contribute to its mode of action. 8 It is concluded that β‐adrenoceptor agonists exert preventive and curative effects on gastric damage induced in the rat. This effect seems specific and mediated through β‐adrenoceptor activation.