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ROLE OF ADRENAL MEDULLA IN MORPHINE‐INDUCED HYPERTHERMIA THROUGH CENTRAL ACTION
Author(s) -
WALLENSTEIN MARTIN C.
Publication year - 1982
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1982.tb09255.x
Subject(s) - adrenal medulla , morphine , hyperthermia , adrenalectomy , endocrinology , denervation , medicine , medulla , adrenal gland , catecholamine
1 The role of the adrenal glands, in morphine‐induced hyperthermia was studied in normal, chemically‐sympathectomized, adrenalectomized, adrenal‐demedullated or splanchnicotomized rats. 2 In restrained female rats, 5 mg/kg morphine produced hyperthermia whereas 20 mg/kg and 40 mg/kg produced hypothermia. 3 After adrenalectomy, 5 mg/kg morphine did not produce hyperthermia. 4 After adrenal‐demedullation or adrenal‐denervation (splanchnicotomy), 5 mg/kg morphine did not produce hyperthermia. 5 The results suggest that, in the rat, the adrenal medulla plays an important role in morphine‐induced hyperthemia, and that morphine acts centrally to stimulate the medulla.