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THE EFFECT OF CIMETIDINE ON BASAL GASTRIC ACID SECRETION IN THE RAT
Author(s) -
BROUGHTON N.S.,
MORRIS J.F.
Publication year - 1982
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1982.tb09253.x
Subject(s) - cimetidine , gastric acid , basal (medicine) , secretion , medicine , endocrinology , chemistry , insulin
1 The effect of cimetidine on the basal gastric acid secretion of the rat has been investigated in an anaesthetized lumen‐perfused preparation. 2 Six rats previously given large doses of cimetidine orally showed no significant difference in basal gastric acid secretion when compared with six control rats. 3 Intravenous administration of 1 mg and 8 mg of cimetidine failed to inhibit significantly basal gastric acid secretion. 4 Although rats with a basal gastric acid secretion above 2.5 μEq/10 min showed a consistent small reduction in basal gastric acid secretion after intravenous cimetidine, this was not seen in rats with a basal gastric acid secretion below 2.5 μEq/10 min. 5 These results contrast sharply with the pronounced inhibition of basal gastric acid secretion by cimetidine in man and the possible reasons for this are discussed. 6 The results are also contrasted with previous work on gastric fistula rats which showed higher basal gastric acid secretion and significant inhibition by cimetidine.