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EFFECT OF ETYA AND BW 755c ON ARACHIDONATE‐INDUCED CONTRACTIONS IN THE GUINEA‐PIG ISOLATED TRACHEA
Author(s) -
MITCHELL H.W.
Publication year - 1982
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1982.tb09250.x
Subject(s) - arachidonic acid , guinea pig , lipoxygenase , endocrinology , medicine , chemistry , biology , anatomy , biochemistry , enzyme
1 Arachidonic acid caused larger contractions in indomethacin‐treated guinea‐pig trachea than in control tracheae. 2 No change in contractions was obtained in tracheae treated with 5, 8, 11, 14, eicosatetraynoic acid (ETYA 10 μ m ). 3 ETYA (100 μ m ) blocked the effect of indomethacin on arachidonic acid‐induced responses. Likewise BW 755c (113 μ m ) reversed the effect of indomethacin. 4 The results show that arachidonate lipoxygenase products may be responsible for the contractile responses seen in the presence of indomethacin.