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A COMPARATIVE STUDY OF β‐ADRENOCEPTORS IN HUMAN AND PORCINE LUNG PARENCHYMA STRIP
Author(s) -
GOLDIE ROY G.,
PATERSON JAMES W.,
WALE JANET L.
Publication year - 1982
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1982.tb09249.x
Subject(s) - parenchyma , lung , medicine , pathology , anatomy , biology
1 Responses to (±)‐isoprenaline (Iso), (−)‐adrenaline (Adr) and (−)‐noradrenaline (NA) were compared in isolated preparations of human and porcine lung parenchyma strip. 2 The order of relaxant potencies of these catecholamines in both human and porcine lung parenchyma was Iso > Adr > NA (1:0.24:0.01, human; 1:0.21:0.01, pig). These results suggest that β 2 ‐adrenoceptors predominate in both types of lung parenchyma strip. 3 pA 2 values for the β‐adrenoceptor antagonist, propranolol (non‐selective), with Iso as the agonist, in human and porcine lung strips were 7.84 and 7.83 respectively and for atenolol were 6.50 and 5.35 respectively. Taken as a whole, results indicate the existence of an apparently homogeneous population of β 2 ‐adrenoceptors in porcine parenchyma strip, while both β 1 and β 2 ‐adrenoceptors were revealed in human lung parenchyma.