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THE EFFECTS OF POSTLIGATION ADMINISTRATION OF ORG 6001 AND DISOPYRAMIDE ON EARLY ISCHAEMIA‐INDUCED ARRHYTHMIAS IN THE ANAESTHETIZED RAT
Author(s) -
MARSHALL R.J.,
MUIR A.W.,
WINSLOW EILEEN
Publication year - 1982
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1982.tb09245.x
Subject(s) - disopyramide , pharmacology , ligation , medicine , anti arrhythmia agents , anesthesia , cardiology , atrial fibrillation
The effects of intravenous doses of Org 6001 and disopyramide (10 mg/kg) known to confer protection against early postligation‐induced arrhythmias in the anaesthetized rat when given prophylactically, were assessed following postligation administration. When given 1 min after ligation both drugs greatly reduced the incidence of ventricular fibrilloflutter and completely prevented electrical deaths (45% in the controls). Protection was also seen when the drugs were given just before the expected onset of arrhythmias (4.5 min postligation).