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AGGREGATION OF RAT NEUTROPHILS BY NUCLEOTIDE TRIPHOSPHATES
Author(s) -
FORDHUTCHINSON A.W.
Publication year - 1982
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1982.tb09229.x
Subject(s) - uridine triphosphate , adenosine triphosphate , adenosine diphosphate , nucleotide , guanosine , uridine diphosphate , atp hydrolysis , guanosine triphosphate , biochemistry , uridine , nucleoside diphosphate kinase , adenosine , chemistry , nucleotide salvage , cytidine , biology , platelet , enzyme , atpase , rna , platelet aggregation , immunology , gene
1 Adenosine 5′‐triphosphate (ATP) and uridine 5′‐triphosphate (UTP) at concentrations of 3 × 10 −7 m and greater cause a rapid partially reversible aggregation of rat polymorphonuclear leucocytes. 2 Other neucleotide phosphates are much less active at producing aggregation responses; the agonist potencies being UTP > ATP > guanosine 5′‐triphosphate, cytidine 5′‐triphosphate, thymidine 5′‐triphosphate; ATP > adenosine 5′‐diphosphate (ADP) > adenosine 5′‐monophosphate (AMP); and ADP > uridine 5′‐diphosphate, thymidine 5′‐diphosphate, guanosine 5′‐diphosphate, cytidine 5′‐diphosphate. Adenosine is inactive. 3 The hydrolysis resistant analogues of ATP, α‐β‐methylene ATP and β‐γ‐methylene ATP, do not cause neutrophil aggregation suggesting that hydrolysis of ATP and UTP may be required to initiate the aggregation response. 4 It is postulated that ATP and UTP may be important stimulants of neutrophil function and may be involved in the adherence of these cells to the vascular endothelium.