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INHIBITION OF ADRENALINE‐INDUCED PLATELET AGGREGATION BY THE α‐ADRENOCEPTOR BLOCKING DRUG BENEXTRAMINE
Author(s) -
BELLEAU B.,
BENFEY B.G.,
MELCHIORRE C.,
MONTAMBAULT M.
Publication year - 1982
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1982.tb09214.x
Subject(s) - phenoxybenzamine , postsynaptic potential , potency , blocking (statistics) , chemistry , antagonist , adrenergic receptor , pharmacology , platelet aggregation , platelet , medicine , drug , epinephrine , endocrinology , propranolol , receptor , in vitro , biochemistry , statistics , mathematics
1 The activity of the irreversible α‐adrenoceptor blocking drug, benextramine, was determined in human platelets. 2 Compared to its postsynaptic and presynaptic α‐adrenoceptor blocking potency, benextramine had a very low potency as an antagonist of adrenaline‐induced platelet aggregation. 3 The results confirm the previous observation with the irreversible α‐adrenoceptor blocking drug, phenoxybenzamine, that platelet α‐adrenoceptors differ from postsynaptic and presynaptic α‐adrenoceptors.