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THE ACTION OF PORCINE GLUCAGON ON THE MOTILITY OF THE CANINE DUODENUM AND JEJUNUM
Author(s) -
EVANS D.F.,
FOSTER G.E.,
HARDCASTLE J.D.,
JOHNSON F.,
WRIGHT J.W.
Publication year - 1982
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1982.tb09213.x
Subject(s) - jejunum , duodenum , glucagon , stimulation , medicine , ileum , intestinal motility , endocrinology , motility , bolus (digestion) , migrating motor complex , chemistry , biology , insulin , genetics
1 Intravenous bolus doses of porcine glucagon of 0.001 −0.05 mg kg −1 caused intense stimulation of the duodenum and jejunum of the dog. 2 Intravenous infusion of porcine glucagon at 0.025 −0.05 mg kg −1 h −1 caused similar stimulation. In both cases the stimulation was phasic in nature. 3 Stimulation of the duodenum and jejunum following glucagon was accompanied by a decrease in frequency of the intestinal basic electrical rhythm (BER). No change was seen in the intervals between successive periods of phase III motor activity.