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THE ACTIONS OF LEUKOTRIENES C 4 AND D 4 ON GUINEA‐PIG ISOLATED HEARTS
Author(s) -
LETTS L.G.,
PIPER PRISCILLA J.
Publication year - 1982
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1982.tb09203.x
Subject(s) - contractility , leukotriene , guinea pig , leukotriene c4 , medicine , leukotriene d4 , chemistry , cardiology , asthma
1 Infusions of leukotrienes C 4 (LTC 4 ) and LTD 4 (5 min; 4 × 10 −10 ‐2 × 10 −8 m ) produced dose‐dependent decreases in coronary flow in Langendorff preparations of guinea‐pig isolated hearts. 2 LTC 4 was more active than LTD 4 and produced a greater reduction in coronary flow. 3 LTC 4 and LTD 4 also caused reduction in contractility in perfused hearts but not in isolated atria or driven ventricular strips. 4 There was a greater reduction in contractility to LTD 4 compared with LTC 4 at doses which produced approximately 50% reduction in coronary flow. 5 Indomethacin (1.4 × 10 −5 m ) inhibited the effects of LTC 4 but only reduced the initial LTD 4 ‐induced effects. 6 The effects of FPL 55712 (3.8 × 10 −6 m ) were similar to those of indomethacin. 7 LTC 4 and LTD 4 may therefore contribute to the abnormalities of cardiac function that occur in immediate hypersensitivity reactions, particularly reduction in coronary flow.