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INCREASED HISTAMINE‐OUTPUT FROM THE ISOLATED GASTRIC MUCOSA OF THE RAT IN RESPONSE TO PENTAGASTRIN AND METHACHOLINE
Author(s) -
MAIN I.H.M.,
PEARCE J.B.
Publication year - 1982
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1982.tb09190.x
Subject(s) - histamine , pentagastrin , methacholine , endocrinology , medicine , gastrin , secretagogue , parietal cell , stimulation , gastric acid , secretion , chemistry , gastric mucosa , sham feeding , biology , stomach , respiratory disease , lung
1 A rat isolated gastric mucosal preparation was used to monitor histamine output and acid secretion during stimulation by different secretagogues. 2 In non‐stimulated preparations, spontaneous histamine output decreased over 450 min. 3 Stimulation of secretion with 4(5)‐methylhistamine or dibutyryl cyclic adenosine 3′,5′‐monophosphate (db cyclic AMP) and theophylline did not influence histamine output. 4 Pentagastrin, gastrin and methacholine increased both acid secretion and histamine output. Pentagastrin and gastrin mobilized six times more histamine in relation to acid secretion than did methacholine. 5 Spontaneous histamine output and secretagogue‐induced increases were unaffected by changes in external Ca 2+ (0.0 to 7.2 m m ) or Mg 2+ (1.2 to 4.8 m m ). 6 These results support the hypothesis that mucosal histamine plays a more important role in the action of gastrin than of cholinomimetics on the parietal cell.