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DISSOCIATION OF β‐ADRENOCEPTOR‐INDUCED EFFECTS ON AMYLASE SECRETION AND CYCLIC ADENOSINE 3′,5′‐MONOPHOSPHATE ACCUMULATION
Author(s) -
CARLSÖÖ BENGT,
DANIELSSON ÅKE,
HENRIKSSON ROGER,
IDAHL LARSÅKE
Publication year - 1982
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1982.tb09184.x
Subject(s) - endocrinology , medicine , chemistry , terbutaline , agonist , amylase , adenosine , dissociation constant , isoprenaline , secretion , adrenergic receptor , cyclic adenosine monophosphate , receptor , enzyme , biology , stimulation , biochemistry , asthma
1 By using a multi‐channel microperifusion system the effects of noradrenaline, the β 1 ‐adrenoceptor agonist prenalterol, and the β 2 ‐selective agonist terbutaline were studied on amylase release and cyclic adenosine 3′,5′‐monophosphate (cyclic AMP) content in rat parotid and guinea‐pig submandibular glands. 2 Noradrenaline caused significant amylase discharge and cyclic AMP accumulation. 3 Prenalterol was as effective as noradrenaline in causing amylase release but did not significantly affect the cyclic AMP content. 4 Terbutaline stimulated cyclic AMP accumulation, but had little effect on amylase secretion. 5 The present study reveals that there is a dissociation of the β‐adrenoceptor‐induced amylase release and cyclic AMP formation, and that this dissociation may be due to different β‐adrenoceptor subtypes.