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INHIBITION BY THE TETRAMINE DISULPHIDE, BENEXTRAMINE, OF CARDIAC CHRONOTROPIC HISTAMINE H 2 ‐RECEPTOR‐MEDIATED EFFECTS
Author(s) -
BELLEAU B.,
BENFEY B.G.,
BENFEY T.J.,
MELCHIORRE C.
Publication year - 1982
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1982.tb09176.x
Subject(s) - chronotropic , histamine , chemistry , guinea pig , medicine , endocrinology , cimetidine , histamine h2 receptor , receptor , atrium (architecture) , histamine receptor , pharmacology , biology , biochemistry , antagonist , heart rate , blood pressure , atrial fibrillation
1 Benextramine (N,N'‐bis[ o ‐methoxybenzylamino)‐ n ‐hexyl]cystamine), which irreversibly blocks α‐adrenoceptors and does not inhibit the H 1 ‐receptor‐mediated contractile effect of histamine on guinea‐pig isolated ileum, also did not inhibit the H 1 ‐receptor‐mediated inotropic effect of histamine on guinea‐pig isolated atrium. 2 Benextramine irreversibly inhibited the H 2 ‐receptor‐mediated chronotropic effect of histamine on guinea‐pig isolated atrium. 3 Since its combination with the competitive H 2 ‐receptor blocking drug cimetidine had an additive blocking effect, benextramine appears to act directly on the chronotropic H 2 ‐receptor.