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EFFECT OF CONVERTING ENZYME INHIBITION ON THE RENAL HAEMODYNAMIC RESPONSES TO NORADRENALINE INFUSION IN THE RAT
Author(s) -
ARUNDELL LEWIS A.,
JOHNS EDWARD J.
Publication year - 1982
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1982.tb09173.x
Subject(s) - filtration fraction , renal blood flow , renal function , endocrinology , medicine , vasoconstriction , hemodynamics , blood pressure , plasma renin activity , renin–angiotensin system , kidney , chemistry , angiotensin converting enzyme , renal circulation , angiotensin ii
1 The renal haemodynamic responses to a close arterial infusion of noradrenaline (29.7–177.9 nmol kg −1 h −1 ) were measured in rats anaesthetized with pentobarbitone. Systemic blood pressure was unaffected by noradrenaline infusion at this dose level. Renal blood flow was significantly reduced by 16% while glomerular filtration rate remained unchanged. These responses resulted in a rise in filtration fraction of some 10%. 2 In a separate group of animals, noradrenaline infusion in this manner and at a similar dose rate increased plasma renin activity approximately 3 fold. 3 Continuous infusion of the angiotensin converting enzyme inhibitor, teprotide (3.36 μmol kg −1 h −1 ), had no measurable effect on systemic blood pressure, renal blood flow, glomerular filtration rate or filtration fraction. 4 Infusion of noradrenaline into these animals receiving teprotide caused a significant fall in renal blood flow of 16%. There was a fall in glomerular filtration rate of some 17% which was significantly different from the response observed in the animals not receiving teprotide. There was a consequent small but insignificant fall in filtration fraction. 5 These data show that the regulation of glomerular filtration rate in response to the vasoconstrictor drug, noradrenaline, is partly mediated via the renin‐angiotensin system. They provide evidence for a role of intrarenal angiotensin II in regulating glomerular filtration by causing efferent arteriolar vasoconstriction.