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RELATIVE ACTIVITIES OF SUBSTANCE P‐RELATED PEPTIDES IN THE GUINEA‐PIG ILEUM AND RAT PAROTID GLAND, in vitro
Author(s) -
GATER P.R.,
JORDAN C.C.,
OWEN D.G.
Publication year - 1982
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1982.tb08792.x
Subject(s) - guinea pig , ileum , parotid gland , in vitro , substance p , medicine , endocrinology , chemistry , biology , biochemistry , pathology , neuropeptide , receptor
1 The relative potencies of a series of substance P analogues have been determined for spas‐mogenic activity in the guinea‐pig ileum in vitro and for the release of 86 Rb and α‐amylase activity from rat parotid gland slices in vitro . Equipotent molar ratios (EMR), relative to substance P, were determined for all the compounds. 2 In the rat carotid gland, EC 50 values for amylase release were, on average, 35.5 times greater than those for 86 Rb release. Analysis of Hill plots suggests that spare receptors exist for 86 Rb release but not for amylase release and it is suggested that the stimulus‐response coupling for amylase release may be less efficient than that for 86 Rb release. 3 In the parotid gland, the octapeptide and [