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ANALYSIS OF HISTAMINE RECEPTORS IN THE CENTRAL THERMOREGULATORY MECHANISM OF Mastomys natalensis
Author(s) -
DHAWAN B.N.,
SHUKLA R.,
SRIMAL R.C.
Publication year - 1982
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1982.tb08767.x
Subject(s) - mepyramine , dimaprit , histamine , cimetidine , hypothermia , hyperthermia , histamine h2 receptor , thermoregulation , histamine receptor , medicine , endocrinology , histamine h1 receptor , chemistry , pharmacology , receptor , antagonist , biology
1 The effect of intracerebroventricular (i.c.v.) injection of histamine on the rectal temperature of Mastomys natalensis at ambient temperatures of 10, 24 and 33°C has been studied. 2 Low doses (0.1–1.0 μg) of histamine produced hypothermia while larger doses (5–20 μg) produced dose‐dependent hyperthermia. The hypothermic effect was significantly antagonized by mepyramine while the hyperthermia was blocked by cimetidine. 3 Histamine H 1 ‐receptor agonists, 2‐methyl‐histamine and 2‐pyridyl‐ethylamine, also produced hypothermia which could be blocked by mepyramine. 4 Histamine H 2 ‐receptor agonists, impromidine and dimaprit, produced hyperthermia which was antagonized by cimetidine. 5 Pretreatment of the animals with a β‐adrenoceptor antagonist, MJ1999, did not affect the response to histamine. 6 The hyperthermic effect of histamine (10 μg) was most marked at 10°C and was attenuated at 33°C. 7 It is concluded that both H 1 ‐ and H 2 ‐histamine receptors are present in the brain of Mastomys . The H 1 ‐receptors mediate hypothermia and H 2 ‐receptors hyperthermia.