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CYTOCHROME P‐450‐DEPENDENT O‐DEALKYLASE ACTIVITY IN MAMMALIAN SKIN
Author(s) -
DAMEN FRANK J.M.,
MIER P.D.
Publication year - 1982
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1982.tb08764.x
Subject(s) - hexachlorobenzene , cytochrome , in vitro , pharmacology , chemistry , phenobarbital , biochemistry , biology , enzyme , organic chemistry , pollutant
1 A modified technique for the measurement of O‐dealkylase (ODA) activity in crude homogenates is reported, and its application to skin is described. 2 Large differences in ODA levels were found between different species, no activity being observed in the skin of primates. 3 Induction of cutaneous ODA in mice was achieved by the subcutaneous injection of phenobarbitone, hexachlorobenzene or 20‐methylcholanthrene. 4 Attempts to induce ODA in vitro were unsuccessful.