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THE ROLE OF THE LOCAL ANAESTHETIC PROPERTIES OF β‐ADRENOCEPTOR BLOCKING AGENTS IN ANTAGONIZING CaCl 2 ‐INDUCED ARRHYTHMIAS IN THE RAT
Author(s) -
EVANGELISTA S.,
MAGGI C.A.,
MELI A.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb16808.x
Subject(s) - local anaesthetic , beta adrenoceptor , blocking (statistics) , pharmacology , medicine , adrenergic receptor , anesthesia , adrenergic beta antagonists , bolus (digestion) , chemistry , receptor , propranolol , statistics , mathematics
1 Eight β‐adrenoceptor blocking agents were compared for their ability to antagonize arrhythmias induced by bolus injections of CaCl 2 in rats. 2 Only those β‐blockers possessing local anaesthetic properties were effective in antagonizing this type of arrhythmia and there was a highly significant correlation between antiarrhythmic and local anaesthetic properties. 3 Effects on adrenoceptors seem to play only a minor role in the genesis of this type of arrhythmia.