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MECHANISM OF ANTI‐INFLAMMATORY ACTION OF GLUCOCORTICOIDS: RE‐EVALUATION OF VASCULAR CONSTRICTION HYPOTHESIS
Author(s) -
SUGIO KAZUO,
TSURUFUJI SUSUMU
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb16794.x
Subject(s) - inflammation , constriction , vascular permeability , granuloma , vasodilation , stimulation , endocrinology , medicine , prostaglandin , chemistry , pathology
1 The question whether constriction of local vessels is essential for the anti‐inflammatory action of glucocorticoids in carrageenin‐induced granulomatous inflammation was studied. 2 The vasodilator prostaglandin E 1 injected into the granuloma pouch fluid increased the exudation of plasma protein into the granuloma tissue. 3 Noradrenaline significantly reduced plasma exudation, possibly through α‐adrenoceptor stimulation. 4 Cortisol and dexamethasone in doses sufficient to inhibit vascular permeability were without effect on the blood content in the granuloma tissue. 5 The results suggest that constriction of local vessels does not play an essential role in the anti‐exudative effect of glucocorticoids in chronic proliferative inflammation.