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BIPHASIC MECHANICAL RESPONSES OF THE GUINEA‐PIG ISOLATED ILEUM TO THE VENOM OF THE MARINE SNAIL Conus striatus
Author(s) -
KOBAYASHI JUN'ICHI,
NAKAMURA HIDESHI,
OHIZUMI YASUSHI
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb16790.x
Subject(s) - phentolamine , venom , tetrodotoxin , contraction (grammar) , atropine , ileum , bretylium , conus , guanethidine , chemistry , biology , guinea pig , anatomy , pharmacology , propranolol , medicine , endocrinology , adrenergic , biochemistry , stimulation , receptor
Venom extract of Conus striatus elicited a rhythmic, transient contraction of the guinea‐pig isolated ileum followed by a relaxation at concentrations greater than 1μg/ml, which was abolished by tetrodotoxin and a low‐Na medium. The contraction induced by the venom was inhibited by atropine but not mecamylamine, whereas the relaxation was not affected by bretylium, guanethidine or phentolamine. These results suggest that the contraction of the ileum induced by the venom is due to the excitation of cholinergic nerves, while the relaxation is mediated through non‐adrenergic inhibitory nerves.