Premium
EFFECT OF VERAPAMIL ON THE PULMONARY VASOCONSTRICTOR ACTION OF PROSTAGLANDIN F 2α AND A SYNTHETIC PGH 2 ANALOGUE
Author(s) -
ANGERIO ALLAN D.,
FITZPATRICK THOMAS M.,
KOT PETER A.,
RAMWELL PETER W.,
ROSE JOHN C.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb16777.x
Subject(s) - verapamil , alpha (finance) , chemistry , prostaglandin , endocrinology , medicine , vasoconstrictor agents , arachidonic acid , calcium , pharmacology , vasoconstriction , biochemistry , enzyme , construct validity , patient satisfaction , nursing
1 The vasopressor response to prostaglandin F 2α (PGF 2α ) and to ((15S)‐hydroxy‐11α, 9α‐(epoxymethano)‐prosta‐5Z, 13E‐dienoic acid) (U‐46619) in the canine isolated lung lobe was significantly attenuated following the administration of verapamil. 2 The pressor response to arachidonic acid (AA) was not affected by the presence of verapamil. 3 The pulmonary pressor effect of PGF 2α and U‐46619 is dependent, at least in part, on Ca 2+ influx into vascular smooth muscle cells. 4 The pulmonary pressor response to AA cannot be attributed to PGF 2α or to endoperoxide intermediates but to some other product dependent on intracellular calcium stores.