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ACCUMULATION OF [ 3 H]‐OUABAIN IN FUNCTIONALLY DIFFERENT CANINE CARDIAC TISSUES: DIFFERENTIAL Rb + UPTAKE
Author(s) -
RHEE H.M.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb16774.x
Subject(s) - ouabain , cardiac muscle , biology , chemistry , medicine , endocrinology , biophysics , sodium , organic chemistry
1 In order to understand tissue‐specific differences in sensitivity to ouabain, the distribution of [ 3 H]‐ouabain was investigated in seven functionally different, canine cardiac tissues. 2 Specialized cardiac tissues (e.g., pacemaker or conducting tissues) accumulate much less ouabain than do the contractile tissues such as the left ventricule or the papillary muscle. 3 This study confirms a greater Rb + uptake in the Purkinje fibre than in the contractile tissue. 4 The results disprove the hypothesis that a high accumulation of ouabain in the Purkinje fibre is responsible for the well‐known sensitivity to ouabain in this tissue.