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THE EFFECT OF CIMETIDINE ON BASAL AND STIMULATED PEPSIN SECRETION IN THE ISOLATED WHOLE STOMACH OF THE RAT
Author(s) -
BUNCE K.T.,
GREWAL M.,
PARSONS M.E.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb16769.x
Subject(s) - pepsin , cimetidine , histamine , medicine , endocrinology , atropine , secretion , muscarinic acetylcholine receptor , stimulation , chemistry , stomach , gastric acid , histamine h1 receptor , biology , antagonist , receptor , biochemistry , enzyme
1 The isolated stomach preparation of the immature rat has been used to study the stimulation and inhibition of pepsin secretion. 2 The isolated stomach secretes a basal level of pepsin. High concentrations (10 −3 m) of the H 2 ‐receptor antagonist, cimetidine, and the muscarinic receptor blocking drug, atropine, did not affect this secretion in a manner which was consistently of statistical significance. 3 Concentrations of histamine of 10 −5 M, 10 −4 M and 10 −3 M stimulated maximum levels of pepsin output of 126%, 155% and 299% respectively of control. There was no evidence that this secretion was secondary to the stimulation of acid secretion. 4 Cimetidine (10 −4 m and 10 −3 m) produced a dose‐related inhibition of the pepsin output to 10 −3 M histamine, suggesting that histamine H 2 ‐receptors mediate this response. 5 Atropine (10 −3 m) had no effect on the pepsin response to 10 −3 M histamine, suggesting that muscarinic mechanisms play no part, even modulatory, in this secretion.